Phenotypes Associated with This Genotype

Genotype
MGI:3623679

• Allelic Composition: Fkbp1b^tm1Amks/Fkbp1b^tm1Amks
• Genetic Background: DBA/1LacJ-Fkbp1b^tm1Amks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107733 )

• following strenuous exercise and injection with epinephrine, mutant mice displayed polymorphic ventricular tachycardia followed by death

cardiovascular system

ventricular tachycardia ( J:107733 )

• consistently exhibited exercise-induced cardiac ventricular arrhythmias that cause sudden cardiac death

irregular heartbeat ( J:107733 )

• consistently exhibited exercise-induced cardiac ventricular arrhythmias that cause sudden cardiac death

• cardiac arrhythmias were observed in nonexercised animals

• no evidence of hypertension or cardiac hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
catecholaminergic polymorphic ventricular tachycardia		DOID:0060674	OMIM:PS604772	J:107733