Phenotypes Associated with This Genotype

Genotype
MGI:3623958

• Allelic Composition: Cd38^tm1Lnd/Cd38^tm1Lnd
• Genetic Background: NOD.129P2(B6)-Cd38^tm1Lnd/LtJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:108097 )

• Cd38-deficient NOD mice display higher NAD-mediated T cell death

insulitis ( J:108097 )

• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice

increased susceptibility to autoimmune diabetes ( J:108097 )

• homozygous NOD mutants show significant acceleration in diabetes development compared to wild-type NOD mice; the first diagnosis of diabetes is made at 10 weeks of age while in wild-type NOD mice it occurs at 12 weeks or later; the frequency in null NOD males is 100% by 28 weeks which is higher than the frequency in wild-type NOD males

• diabetes acceleration is seen only when Cd38-deficient bone marrow from NOD mice is transferred to Cd38-deficient recipients

• diabetes onset is assessed by 2 consecutive positive urine glucose tests

endocrine/exocrine glands

insulitis ( J:108097 )

• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice

cellular

increased T cell apoptosis ( J:108097 )

• Cd38-deficient NOD mice display higher NAD-mediated T cell death

hematopoietic system

increased T cell apoptosis ( J:108097 )

• Cd38-deficient NOD mice display higher NAD-mediated T cell death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:108097