Phenotypes Associated with This Genotype

Genotype
MGI:3623976

• Allelic Composition: Parp1^tm1Hsmm/Parp1^tm1Hsmm
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:53360 )

• in response to a diabetogenic streptozotocin dose, null mice do not develop hyperglycemia in the first 7 days and show only a transient 1.7-fold blood glucose increase over untreated control levels on day 21, compared to treated controls which have a gradual increase in blood glucose over this period and still exhibit elevated levels on day 60

• streptozotocin treatment causes beta cell death and atrophy in pancreatic islets from treated wild-type mice over 60 days of observation, but islets from null mice show very little damage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:53360