Phenotypes Associated with This Genotype

Genotype
MGI:3624036

• Allelic Composition: Tg(Ins1-Cat,Tyr)25Pne/0
• Genetic Background: NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:108415 )

• treatment of transgenic NOD mice with cyclophosphamide (CYP) accelerated NOD diabetes; 20 days after injection of CYP 63% of transgenic mice are diabetic compared with 7% of treated controls

immune system

increased susceptibility to autoimmune diabetes ( J:108415 )

• transgenic NOD male mice display a significant acceleration of the onset of spontaneous diabetes (over 85% at 200 days of age) compared to NOD controls (30-40% of male NOD mice)

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:108415 )

• cultured islets of transgenic NOD mice are more sensitive to a mix of cytokines (Il-beta, Tnfa and Ifng) than NOD control islets as revealed by Caspase-3 activity

decreased pancreatic beta cell number ( J:108415 )

• beta cell damage is significantly increased in transgenic mice after CYP injection compared to controls; pancreatic insulin content is only 22% of original level after 8 days compared to 76% in control NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:108415