Phenotypes Associated with This Genotype

Genotype
MGI:3624367

• Allelic Composition: Ctnna2^tm1Mta/Ctnna2^tm1Mta
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:107709 )

• most homozygotes die with 24 hours after birth

nervous system

abnormal hippocampus layer morphology ( J:107709 )

• null mutants show some subtle disorders in laminar formation in the hippocampus

abnormal cerebellum morphology ( J:107709 )

• Purkinje cell migration in the cerebellum is partially blocked in null mice

abnormal neuron morphology ( J:107709 )

• dendrites of cultured hippocampal neurons from null mutants differ in their fine morphology compared to wild-type neurons; many dendritic spines are elongated in mutant neurons, with variable length of the dendritic spines

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:83635