Analysis Tools
mortality/aging
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• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death
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behavior/neurological
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• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
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• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
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• seen at late stages of disease
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nervous system
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• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age
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• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed
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growth/size/body
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• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
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respiratory system
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• occasionally show heavy breathing at 5 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:67909 | |
