Phenotypes Associated with This Genotype

Genotype
MGI:3624685

• Allelic Composition: Mecp2^tm1Jae/Y; Tg(Camk2a-cre)93Kln/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:67909 )

♂ • mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait

decreased locomotor activity ( J:67909 )

♂ • mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body

increased susceptibility to age related obesity ( J:67909 )

♂ • 7 of 11 become overweight and obese at 10 weeks of age or older

♂ • mutants appear healthy for up to 3 months when they begin to gain weight

nervous system

decreased brain weight ( J:67909 )

♂

abnormal hippocampus CA2 region morphology ( J:67909 )

♂ • neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age

abnormal neuron morphology ( J:67909 )

♂ • exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67909