Analysis Tools
mortality/aging
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• at E9.5, mutant embryos show significant degeneration; no mutants are recovered at E10
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embryo
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• at E8.5, mutants shave a flattened ventral surface with no visible fore- or hindgut formation and caudally displaced bulbous neural tissue
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• after E7, the anterior-posterior axis is broadened
• at E7.5 and early head fold stages, embryo adopts and elongated and distorted 'boot-shaped' morphology; mutants show rudimentary anterior neural development with no visible headfolds and recognizable foregut invagination
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• mutant embryos exhibit abnormal rhombomere morphology
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fused somites
(
J:92066
)
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• somites form, but are fused across the midline
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• all mutants show an allantois-like outgrowth of variable size and in 70% of the cases associates with the stalk-like chorionic ectoderm while in the remaining embryos, the allantois terminates blindly in the exocoelomic cavity
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nervous system
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• mutant embryos exhibit abnormal hindbrain development
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• mutant embryos exhibit abnormal rhombomere morphology
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reproductive system
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• most embryos lack primordial germ cells which form at the base of the primordial allantois
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digestive/alimentary system
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• no visible formation of foregut at E8.5
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• no visible formation of hindgut at E8.5
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cellular
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• most embryos lack primordial germ cells which form at the base of the primordial allantois
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