Phenotypes Associated with This Genotype

Genotype
MGI:3624717

• Allelic Composition: Mecp2^tm1.1Bird/Mecp2^tm1.1Bird
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:67910 )

♀ • variable progression of symptoms leads to rapid weight loss and death at about 54 days of age

behavior/neurological

limb grasping ( J:67910 )

♀ • most mutants develop hindlimb clasping after 7 weeks of age

abnormal gait ( J:67910 )

♀ • develop a stiff, uncoordinated gait between 3 and 8 weeks of age

decreased locomotor activity ( J:67910 )

♀ • exhibit reduced spontaneous movement between 3 and 8 weeks of age

growth/size/body

abnormal tooth morphology ( J:67910 )

♀ • frequently exhibit uneven wearing of the teeth

weight loss ( J:67910 )

♀ • variable progression of symptoms leads to rapid weight loss and death at about 54 days of age

respiratory system

abnormal breathing pattern ( J:67910 )

♀ • most mutants exhibit irregular breathing after 3-8 weeks of age

craniofacial

abnormal jaw morphology ( J:67910 )

♀ • frequently exhibit misalignment of the jaws

abnormal tooth morphology ( J:67910 )

♀ • frequently exhibit uneven wearing of the teeth

skeleton

abnormal jaw morphology ( J:67910 )

♀ • frequently exhibit misalignment of the jaws

abnormal tooth morphology ( J:67910 )

♀ • frequently exhibit uneven wearing of the teeth

hearing/vestibular/ear

abnormal hearing physiology ( J:67910 )

♀ • some mutants fail to respond to sound, although neither motor defects nor sensory defects are detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67910