Phenotypes Associated with This Genotype

Genotype
MGI:3624718

• Allelic Composition: Mecp2^tm1.1Bird/Mecp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:67910 )

♀ • acquire hindlimb clasping at ages greater than 3 months

decreased locomotor activity ( J:67910 )

♀ • although heterozygous females initially show no symptoms and raise normal litters, they acquire inertia at ages greater than 3 months

♀ • in an open field test, visit fewer squares, spend more time being immotile and rear less than controls, however this is not due to increased anxiety, as fecal bolus counts, grooming times and time spent in different zones of the field are similar to controls

respiratory system

abnormal breathing pattern ( J:67910 )

♀ • often exhibit breathing irregularities by 9 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:67910