Analysis Tools
cellular
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• superovulated mutant females show a significant reduction in numbers of oocytes collected from the oviducts compared to controls
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homeostasis/metabolism
reproductive system
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• superovulated mutant females show a significant reduction in numbers of oocytes collected from the oviducts compared to controls
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• ovaries of knockout animals often contain small follicles with luteinizing cells surrounding either oocytes or oocyte remnants
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• some secondary stage follicles show oocytes without associated granulosa cells
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• in knockout mice, there are fewer large antral follicles
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• in knockout females, large follicle-like structures enclosing a trapped oocyte are observed
• in superovulated females, some follicles show oocytes lacking cumulus cells
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• in superovualated females, half as many intact cumulus-oocyte complexes are recovered from large antral follicles after 44 hours compared to controls
• cumulus-oocyte complexes isolated from mutant females show reduced or absent cumulus expansion when cultured in the presence of serum and FSH
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• cumulus-oocyte complexes isolated from mutant females may show absent cumulus expansion when cultured in the presence of serum and FSH
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• some secondary stage follicles show oocytes without associated granulosa cells
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• in knockout mice, there are more preantral follicles
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• mutant females ovulate about half as much as wild-type
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• null mice have an average of 1.3 pups per litter over a 6-month period, compared to 10.4 pups/litter for control Smad4tm1.1Rob/Smad4tm1Rob animals which is not different from wild-type litter size
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infertility
(
J:108954
)
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• at 3 months of age, 25% of breeding females are infertile; by 6 months of age, 50% are infertile
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endocrine/exocrine glands
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• ovaries of knockout animals often contain small follicles with luteinizing cells surrounding either oocytes or oocyte remnants
|
|
|
• some secondary stage follicles show oocytes without associated granulosa cells
|
|
|
• in knockout mice, there are fewer large antral follicles
|
|
|
• in knockout females, large follicle-like structures enclosing a trapped oocyte are observed
• in superovulated females, some follicles show oocytes lacking cumulus cells
|
|
|
• in superovualated females, half as many intact cumulus-oocyte complexes are recovered from large antral follicles after 44 hours compared to controls
• cumulus-oocyte complexes isolated from mutant females show reduced or absent cumulus expansion when cultured in the presence of serum and FSH
|
|
|
• cumulus-oocyte complexes isolated from mutant females may show absent cumulus expansion when cultured in the presence of serum and FSH
|
|
|
• some secondary stage follicles show oocytes without associated granulosa cells
|
|
|
• in knockout mice, there are more preantral follicles
|
