Phenotypes Associated with This Genotype

Genotype
MGI:3624726

• Allelic Composition: Zeb2^tm1.2Yhi/Zeb2^tm1.2Yhi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:82084 )

• die sometime around E9.5

nervous system

abnormal neural plate morphology ( J:82084 )

• a sharp boundary between the neural plate and the rest of the ectoderm is absent

absent vagal neural crest cells ( J:82084 )

• lack postotic vagal level neural crest cells

open neural tube ( J:82084 )

• neural tube fails to close

embryo

abnormal cranial neural crest cell migration ( J:82084 )

• cranial neural crest cells do not delaminate nor do they initiate migration

abnormal neural crest cell delamination ( J:82084 )

• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm

absent first pharyngeal arch ( J:82084 )

• the first branchial arch is missing

incomplete embryo turning ( J:82084 )

• do not undergo embryonic turning

embryonic growth arrest ( J:82084 )

• embryos are severely retarded in growth by E9.5

abnormal neural plate morphology ( J:82084 )

• a sharp boundary between the neural plate and the rest of the ectoderm is absent

absent vagal neural crest cells ( J:82084 )

• lack postotic vagal level neural crest cells

open neural tube ( J:82084 )

• neural tube fails to close

craniofacial

absent first pharyngeal arch ( J:82084 )

• the first branchial arch is missing

cellular

abnormal cranial neural crest cell migration ( J:82084 )

• cranial neural crest cells do not delaminate nor do they initiate migration

abnormal neural crest cell delamination ( J:82084 )

• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Mowat-Wilson syndrome		DOID:0060485	OMIM:235730	J:82084