Analysis Tools
mortality/aging
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• mean longevity for males is 166 +/- 6 days compared to 545 +/- 37 days for reciprocal hybrid males
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immune system
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• 20-fold increase in spleen weight by 20 weeks of age
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• infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node
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• enlarged 13-fold at 18 to 20 weeks of age compared to reciprocal hybrid males and 6 fold compared to BXSB males
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• spleen cell responses to phytohemagglutinin and concanavalin A are reduced and response to E. coli lipopolysaccharide is increased
• however, lymph node cell response to concanavalin A is similar to reciprocal hybrid males
• at 4 weeks of age, in vitro proliferation of spleen cells is increased 3-fold compared to cells from reciprocal hybrid males
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• accelerated autoimmune syndrome relative to reciprocal hybrid males
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• high titers of thymotoxic autoantibodies were found between 16 and 20 weeks of age in 15 of 16 males
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• erythrocyte autoantibodies were found in 16 of 17 males between 16 and 20 weeks of age
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• high titers of antinuclear antibody were found between 16 and 20 weeks of age in 14 of 16 males
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homeostasis/metabolism
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• at 23 weeks of age protoporphyrin levels are 543 +/- 368 mg/100 ml packed erythrocytes compared to 39 +/- 1 mg in reciprocal hybrid males
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hematopoietic system
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• 20-fold increase in spleen weight by 20 weeks of age
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growth/size/body
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• 20-fold increase in spleen weight by 20 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:6235 | |
