Phenotypes Associated with This Genotype

Genotype
MGI:3624975

• Allelic Composition: X/Yaa
• Genetic Background: (NZW x BXSB)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:7276 )

♂ • 50% mortality is seen at 4.5 months of age compared to 16 months in reciprocal hybrid males

immune system

abnormal immune serum protein physiology ( J:7276 )

♂ • gp70 immune complexes are detectable earlier and reach higher concentrations compared to reciprocal hybrid males; however, the total concentration of free and complexed gp70 is similar

increased susceptibility to autoimmune disorder ( J:7276 )

♂ • accelerated autoimmune syndrome relative to reciprocal hybrid males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:7276