Phenotypes Associated with This Genotype

Genotype
MGI:3624982

• Allelic Composition: X/Yaa
• Genetic Background: BXSB/MpJScr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:10973 )

♂

immune system

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

♂ • pronounced decrease in CD4+ T cells with age

increased monocyte cell number ( J:10973 )

♂ • monocytosis

increased IgG level ( J:10973 )

♂

increased susceptibility to autoimmune disorder ( J:10973 )

♂ • accelerated autoimmune syndrome

increased anti-nuclear antigen antibody level ( J:10973 )

♂ • anti-nuclear antibody levels are elevated at 3 to 5 months of age

glomerulonephritis ( J:10973 )

♂ • develop severe proliferative glomerulonephritis by 3 to 5 months of age

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:10973 )

♂ • pronounced decrease in CD4+ T cells with age

increased monocyte cell number ( J:10973 )

♂ • monocytosis

increased IgG level ( J:10973 )

♂

renal/urinary system

glomerulonephritis ( J:10973 )

♂ • develop severe proliferative glomerulonephritis by 3 to 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:10973