About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3624987
Allelic
Composition
Tg(Ckm-LPL)MRze/0
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at 8-12 months of age

growth/size/body
• gain weight slower than controls in the initial few weeks after birth and after 8 weeks of age, reach only 90% of the weight of controls
• at 10 to 12 weeks of age, start to slowly lose weight

homeostasis/metabolism
• 56.5% decrease in plasma triglyceride levels at 2-3 months of age and lower levels seen over the lifespan of mutants
• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
• 2 to 3-fold increase in succinated dehydrogenase activity
• 8-fold increase in catalase activity in skeletal muscle

muscle
• at 5 months of age, exhibit an increase in the number of mitochondria in the subsarcolemmic, perinuclear, and intermyofibrillar position of muscle fibers
• increase in the number of mitochondria in myocytes
• large increase in the number of peroxisomes in skeletal muscle
• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
• at 5 months of age, exhibit a moderate loss of muscle tissue

adipose tissue
• at 5 months of age, exhibit a moderate loss of adipose tissue

cardiovascular system
• increase in the number of mitochondria in myocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myopathy DOID:423 J:101818


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory