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Phenotypes Associated with This Genotype
Genotype
MGI:3624987
Allelic
Composition
Tg(Ckm-LPL)MRze/0
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at 8-12 months of age

growth/size/body
• gain weight slower than controls in the initial few weeks after birth and after 8 weeks of age, reach only 90% of the weight of controls
• at 10 to 12 weeks of age, start to slowly lose weight

homeostasis/metabolism
• 56.5% decrease in plasma triglyceride levels at 2-3 months of age and lower levels seen over the lifespan of mutants
• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
• 2 to 3-fold increase in succinated dehydrogenase activity
• 8-fold increase in catalase activity in skeletal muscle

muscle
• at 5 months of age, exhibit an increase in the number of mitochondria in the subsarcolemmic, perinuclear, and intermyofibrillar position of muscle fibers
• increase in the number of mitochondria in myocytes
• large increase in the number of peroxisomes in skeletal muscle
• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
• at 5 months of age, exhibit a moderate loss of muscle tissue

adipose tissue
• at 5 months of age, exhibit a moderate loss of adipose tissue

cardiovascular system
• increase in the number of mitochondria in myocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myopathy DOID:423 J:101818


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory