mortality/aging
• die at 8-12 months of age
|
growth/size/body
• gain weight slower than controls in the initial few weeks after birth and after 8 weeks of age, reach only 90% of the weight of controls
|
weight loss
(
J:101818
)
• at 10 to 12 weeks of age, start to slowly lose weight
|
homeostasis/metabolism
• 56.5% decrease in plasma triglyceride levels at 2-3 months of age and lower levels seen over the lifespan of mutants
|
• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
|
• 2.6-fold increase
|
• 2 to 3-fold increase in succinated dehydrogenase activity
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• 8-fold increase in catalase activity in skeletal muscle
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muscle
• 2.6-fold increase
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• at 5 months of age, exhibit an increase in the number of mitochondria in the subsarcolemmic, perinuclear, and intermyofibrillar position of muscle fibers
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• increase in the number of mitochondria in myocytes
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• large increase in the number of peroxisomes in skeletal muscle
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• moderate increase in muscle glycogen deposition in vesicles or diffusely dispersed in the sarcoplasma at 5 months of age
|
adipose tissue
• at 5 months of age, exhibit a moderate loss of adipose tissue
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cardiovascular system
• increase in the number of mitochondria in myocytes
|