Phenotypes Associated with This Genotype

Genotype
MGI:3625063

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: NOD.Cg-Il4^tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:85924 )

• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

immune system

insulitis ( J:85924 )

• equal degrees of insulitis are detected at 5 weeks in transgenic IL4-deficient NOD mice and control transgenic NOD mice

decreased susceptibility to autoimmune diabetes ( J:85924 )

• Il4-deficient transgenic NOD mice do not show early or frequent diabetes compared to control transgenic NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:85924