Phenotypes Associated with This Genotype

Genotype
MGI:3626074

cx12

• Allelic Composition: Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh; Ins2^Akita/Ins2⁺
• Genetic Background: B6.Cg-Ins2^Akita Bdkrb2^tm1Jfh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:108948 )

• mice have much shorter lifespan than wild-type; 909 days (wt) vs 246 days (mutant)

cellular

abnormal spermatogonia morphology ( J:108948 )

♂ • in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age

abnormal mitochondrial chromosome morphology ( J:108948 )

• mutants display increased mitochondrial DNA damage compared to single mutants or wild-type mice at 12 months of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:108948 )

♂ • double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age

abnormal Leydig cell morphology ( J:108948 )

♂ • double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age

reproductive system

abnormal spermatogonia morphology ( J:108948 )

♂ • in double mutant males, severe loss of spermatogonia is observed and atrophy of spermatic cords is prevalent at 12 months of age

abnormal seminiferous tubule morphology ( J:108948 )

♂ • double mutants have an increased frequency of apoptotic cells in the seminiferous tubules at 12 months of age

abnormal Leydig cell morphology ( J:108948 )

♂ • double mutant males display numerous pigmented vacuoles in Leydig cells in the testes at 12 months of age

abnormal spermatic cord morphology ( J:108948 )

♂ • double mutant males show atrophy of the spermatic cords at 12 months of age

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:108948 )

• intestinal villi in mutants have a greater frequency of apoptotic cells

adipose tissue

decreased subcutaneous adipose tissue amount ( J:108948 )

• mutants have almost no subcutaneous fat

skeleton

kyphosis ( J:108948 )

• double mutants exhibit marked kyphosis

decreased bone mineral density ( J:108948 )

• double mutants have significantly reduced bone density compared to wild-type or single mutant mice

integument

decreased subcutaneous adipose tissue amount ( J:108948 )

• mutants have almost no subcutaneous fat

alopecia ( J:108948 )

• most mutants show significant alopecia by 12 months of age