Phenotypes Associated with This Genotype

Genotype
MGI:3628776

hm1

• Allelic Composition: H2^k/H2^k
• Genetic Background: NOD.Cg-H2^k

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:14178 )

• after cyclophosphamide treatment, mice develop diabetes at 6-7 months of age

endocrine/exocrine glands

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-8 months of age; with cyclophosphamide treatment, a 6-7 months of age, mild periinsulitis is seen

immune system

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-8 months of age; with cyclophosphamide treatment, a 6-7 months of age, mild periinsulitis is seen

increased susceptibility to autoimmune diabetes ( J:14178 )

• by 7 months of age, no mice develop diabetes; between 9-17 months of age, some mice develop diabetes