Phenotypes Associated with This Genotype

Genotype
MGI:3628828

• Allelic Composition: Dnmt3b^tm6Enl/Dnmt3b^tm7Enl
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:106540 )

• almost no (only 1) homozygous mice survive to weaning

neonatal lethality, incomplete penetrance ( J:106540 )

• normal numbers of pups are born but most die within 24 hours

growth/size/body

abnormal nasal bone morphology ( J:106540 )

• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3b^tm7Enl mutants

decreased birth weight ( J:106540 )

• at birth, mutants are less than 2/3 the weight of normal littermates

craniofacial

abnormal nasal bone morphology ( J:106540 )

• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3b^tm7Enl mutants

skeleton

abnormal nasal bone morphology ( J:106540 )

• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3b^tm7Enl mutants

immune system

increased thymocyte apoptosis ( J:106540 )

• at P1, many thymocytes are dead or dying

decreased thymocyte number ( J:106540 )

hematopoietic system

increased thymocyte apoptosis ( J:106540 )

• at P1, many thymocytes are dead or dying

decreased thymocyte number ( J:106540 )

cellular

increased thymocyte apoptosis ( J:106540 )

• at P1, many thymocytes are dead or dying

endocrine/exocrine glands

increased thymocyte apoptosis ( J:106540 )

• at P1, many thymocytes are dead or dying

decreased thymocyte number ( J:106540 )

respiratory system

abnormal nasal bone morphology ( J:106540 )

• skeletons of newborn mutants show similar defect to that seen in adult Dnmt3b^tm7Enl mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
immunodeficiency-centromeric instability-facial anomalies syndrome 1		DOID:0090008	OMIM:242860	J:106540