Phenotypes for Il6 MGI:3629043 MGI Mouse

decreased pro-B cell number ( J:117320 )

• the percentage of CD19⁺ B cell progenitors in the bone marrow is decreased from 58% to 35%

decreased interferon-gamma secretion ( J:123351 )

• after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, reduced interferon gamma production is observed

increased interleukin-4 secretion ( J:123351 )

• after restimulation of spleen cells with keyhole limpet hemocyanin one week following immunization of mutant mice, enhanced Il-4 secretion is observed

abnormal interleukin-6 secretion ( J:109359 )

• intraperitoneal administration of LPS does not induce production of Il6 in the livers of mutants compared to wild-type where expression is increase

decreased susceptibility to induced arthritis ( J:208213 )

• mice treated with collagen II exhibit a lack of disease incident with normal joints compared with wild-type mice

increased body temperature ( J:105279 , J:136166 )

• injection of Il1beta results in body temperature elevation by about 0.5C (J:136166)

abnormal glucose homeostasis ( J:109359 )

• inhibition of hepatic glucose production by ICV infusion of insulin is attenuated

• inhibition of hepatic glucose production assessed by a euglycemic hyperinsulinemic clamp is also attenuated

decreased glucagon secretion ( J:139138 )

• decreased fasting glucagon levels on a high fat diet

decreased insulin secretion ( J:139138 )

• decreased fasting insulin levels on a high fat diet

impaired glucose tolerance ( J:139138 )

• impaired glucose tolerance on a high fat diet

decreased pro-B cell number ( J:117320 )

• the percentage of CD19⁺ B cell progenitors in the bone marrow is decreased from 58% to 35%

abnormal emotion/affect behavior ( J:146951 )

behavioral despair ( J:146951 )

• increased latency to "give up" in a forced swim test

increased anxiety-related response ( J:96218 , J:146951 )

• significantly decreased time spent in the open arms of an elevated maze (J:96218)

• significantly decreased number of entries into the open arms of an elevated maze (J:96218)

• less time spent in the illuminated areas of a light-dark box (J:146951)

increased fear-related response ( J:146951 )

• lower latency to escape adverse stimuli

• fewer failures to escape adverse stimuli

increased locomotor activity ( J:96218 )

• increased locomotor activity in open field tests

abnormal sleep pattern ( J:105279 , J:136166 )

• increased time in non-REM sleep after sleep deprivation persists longer than for controls but increase in time is equivalent (J:105279)

• injection of Il1beta results in reduced dark phase wakefulness (J:136166)

• injection of Il1beta results in increased non REM sleep (J:136166)

abnormal frequency of paradoxical sleep ( J:105279 )

• 30% increased time in REM sleep over a 24 hour period

• most extra REM sleep occurs in the light cycle

• length of REM bouts is normal but number of bouts increases

abnormal pancreatic alpha cell mass ( J:139138 )

• alpha cell mass fails to increase on a high fat diet as it does in controls