Phenotypes Associated with This Genotype

Genotype
MGI:3629084

• Allelic Composition: Ctse^tm1Kjy/Ctse^tm1Kjy
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-positive T cell number ( J:108745 )

• homozygotes housed under conventional conditions have an increased ratio of CD4+CD8+ T cells among splenic lymphocytes compared to wild-type

increased eosinophil cell number ( J:108745 )

• peripheral blood has an increased number of eosinophils compared to that of mice raised under SPF conditions

increased IgE level ( J:108745 )

• in 14-week old homozygotes raised under conventional conditions from birth, serum IgE is ~10-fold higher than in wild-type animals;

increased circulating interleukin-1 beta level ( J:108745 )

• accumulation and reduced turnover of Il18 and Il1b is observed in homozygotes raised under conventional conditions

increased circulating interleukin-18 level ( J:108745 )

• accumulation and reduced turnover of Il18 and Il1b is observed in homozygotes raised under conventional conditions

increased interleukin-4 secretion ( J:108745 )

• amounts of Il4 and Il5 in supernatants of stimulated cultures spleen cells are 6-fold and 3-fold greater respectively for mutants compared to wild-type

increased interleukin-5 secretion ( J:108745 )

• amounts of Il4 and Il5 in supernatants of stimulated cultures spleen cells are 6-fold and 3-fold greater respectively for mutants compared to wild-type

dermatitis ( J:108745 )

• homozygous nulls develop dermatitis similar to atopic dermatitis seen in humans

• mutants raised under conventional conditions show increased sensitivity to hapten-induced experimental contact dermatitis compared to wild-type littermates and NC mice; rate of development and severity are greater

• 5 weeks after administration of TCNB, abscesses with infiltration and thickening of the epidermis is apparent in mutant mice

hematopoietic system

increased double-positive T cell number ( J:108745 )

• homozygotes housed under conventional conditions have an increased ratio of CD4+CD8+ T cells among splenic lymphocytes compared to wild-type

increased eosinophil cell number ( J:108745 )

• peripheral blood has an increased number of eosinophils compared to that of mice raised under SPF conditions

increased IgE level ( J:108745 )

• in 14-week old homozygotes raised under conventional conditions from birth, serum IgE is ~10-fold higher than in wild-type animals;

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:108745 )

• accumulation and reduced turnover of Il18 and Il1b is observed in homozygotes raised under conventional conditions

increased circulating interleukin-18 level ( J:108745 )

• accumulation and reduced turnover of Il18 and Il1b is observed in homozygotes raised under conventional conditions

integument

dermatitis ( J:108745 )

• homozygous nulls develop dermatitis similar to atopic dermatitis seen in humans

• mutants raised under conventional conditions show increased sensitivity to hapten-induced experimental contact dermatitis compared to wild-type littermates and NC mice; rate of development and severity are greater

• 5 weeks after administration of TCNB, abscesses with infiltration and thickening of the epidermis is apparent in mutant mice

alopecia ( J:108745 )

mixed cellular infiltration to dermis ( J:108745 )

• dermis of homozygous mice has a large accumuation of eosinophils, mast cells, macrophages and lymphocytes

epidermal hyperplasia ( J:108745 )

thick epidermis ( J:108745 )

• epidermis is thickened by hyperplasia

reddish skin ( J:108745 )

skin lesions ( J:108745 )

• under conventional housing conditions, homozygous mice develop spontaneous skin atopic dermatitis-like lesions; cultured samples from lesions identified S. aureus as a preferential bacterium

• lesions of various grades are apparent on the face, neck, ears, nose and dorsal skin of mice depending on the age and duration of exposure to conventional conditions; onl a small percentage of heterozygotes developed lesions under the same conditions

• 50-week old animals showed more severe lesions than 14-week old mice; if mice are raised in conventional conditions from time of birth, lesions become apparent at 10 weeks of age and the time for induction of dermatitis decreases with age at time of transfer to conventional housing

• homozygotes at 50 weeks of age display other clinical signs of dermatitis such as itching, crust formation, and erosion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:108745