Phenotypes Associated with This Genotype

Genotype
MGI:3629728

• Allelic Composition: Nfatc2^tm1Glm/Nfatc2^tm1Glm; Nfatc4^tm1Grc/Nfatc4^tm1Grc
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:109139 )

decreased grip strength ( J:109139 )

• mutants display decreased grip strength compared to controls

abnormal locomotor activation ( J:109139 )

abnormal social/conspecific interaction behavior ( J:109139 )

• mutants show increased social interaction

craniofacial

abnormal cranium morphology ( J:109139 )

• mice have shortened anterior parts of the skull

abnormal neurocranium morphology ( J:109139 )

• mice have a reduced length between the intersection of the parietal and interparietal bones and the nasale

abnormal zygomatic arch morphology ( J:109139 )

• there is a narrowed gap between the anterior aspects of the zygomatic arches

abnormal mandible morphology ( J:109139 )

• double knockouts have shortened distance between numerous landmarks for measuring mandible morphology

muscle

hypotonia ( J:109139 )

skeleton

abnormal cranium morphology ( J:109139 )

• mice have shortened anterior parts of the skull

abnormal neurocranium morphology ( J:109139 )

• mice have a reduced length between the intersection of the parietal and interparietal bones and the nasale

abnormal zygomatic arch morphology ( J:109139 )

• there is a narrowed gap between the anterior aspects of the zygomatic arches

abnormal mandible morphology ( J:109139 )

• double knockouts have shortened distance between numerous landmarks for measuring mandible morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:109139