Phenotypes Associated with This Genotype

Genotype
MGI:3629751

• Allelic Composition: Ar^tm1(AR)Dmr/Y; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

reproductive system

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:108849