endocrine/exocrine glands
• transgenic mice develop sialadenitis and severity is associated with diabetes development
|
immune system
• transgenic mice develop sialadenitis and severity is associated with diabetes development
|
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
|
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
|
• incidence of diabetes (5/20) is lower than in MHC class II-deficient mice expressing the DQ8 transgene where incidence is 3-fold higher (73%)
|
hematopoietic system
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
|
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
|
digestive/alimentary system
• transgenic mice develop sialadenitis and severity is associated with diabetes development
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:68641 |