Phenotypes Associated with This Genotype

Genotype
MGI:3639133

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru; Tg(HLA-DQA1,HLA-DQB1)1Dv/0; Tg(HLA-DRB1)31Dmz/0; Tg(Ins2-CD80)3B7Flv/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:68641 )

• transgenic mice develop sialadenitis and severity is associated with diabetes development

abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )

• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line

abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )

• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

decreased susceptibility to autoimmune diabetes ( J:68641 )

• incidence of diabetes (blood glucose >250 mg/dl; 5/22, 23%) is lowered from incidence in MHC class II-deficient mice expressing the DQ8 transgene (73%) and similar to deficient mice transgenic for DR4

endocrine/exocrine glands

salivary gland inflammation ( J:68641 )

• transgenic mice develop sialadenitis and severity is associated with diabetes development

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )

• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line

abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )

• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

digestive/alimentary system

salivary gland inflammation ( J:68641 )

• transgenic mice develop sialadenitis and severity is associated with diabetes development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:68641