Analysis Tools
mortality/aging
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• some homozygotes display symptoms of systemic lupus erythematosus at 6-8 months of age and die
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immune system
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• 17/49 homozygotes exhibit splenomegaly
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• Background Sensitivity: on a mixed 129/B6 background, mice develop symptoms similar to systemic lupus erythematosus
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• mice show anti-nuclear antibodies
• 56% of male mice and 73% of female mice display anti-nuclear antibodies compared to 15% of male and 35% of female wild-type mice
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• 21/49 show perivascular leukocytic infiltration in the kidney
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• in males, 19% show glomerulonephritis compared to 0% of wild-type; 31% of female heterozygotes show glomerulonephritis compared to 12% in wild-type
• numbers in females are likely higher because numerous deficiet female animals could not be analyzed due to high autolysis
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hematopoietic system
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• 17/49 homozygotes exhibit splenomegaly
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renal/urinary system
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• 21/49 show perivascular leukocytic infiltration in the kidney
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• in males, 19% show glomerulonephritis compared to 0% of wild-type; 31% of female heterozygotes show glomerulonephritis compared to 12% in wild-type
• numbers in females are likely higher because numerous deficiet female animals could not be analyzed due to high autolysis
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growth/size/body
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• 17/49 homozygotes exhibit splenomegaly
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:62549 | |
