Phenotypes Associated with This Genotype

Genotype
MGI:3639677

• Allelic Composition: Gpr132^tm1Witt/Gpr132^tm1Witt
• Genetic Background: involves: 129X1/SvJ * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte physiology ( J:69473 )

increased B cell proliferation ( J:69473 )

• hyperresponsive to surface IgM crosslinking agents

increased T cell proliferation ( J:69473 )

• enhanced proliferative response to T cell receptor stimulation, even in younger mice

increased immunoglobulin level ( J:69473 )

• kappa and lambda light chain levels elevated

increased IgA level ( J:69473 )

• in older mice

increased IgG1 level ( J:69473 )

• elevated IgG1 levels in older mice

abnormal immune system organ morphology ( J:69473 )

• although normal in young mice, after 1 year of age, secondary lymph nodes become grossly enlarged

enlarged spleen ( J:69473 )

• expanded numbers of T and B lymphocytes

abnormal lymph node morphology ( J:69473 )

• disrupted architecture

• 3-6X increase of single positive T lymphocytes

• 2-3X increase of B220+ B lymphocytes

enlarged inguinal lymph nodes ( J:69473 )

• rarely is enlarged in young mice

increased anti-nuclear antigen antibody level ( J:69473 )

• increased autoantibodies to nuclear antigens

increased inflammatory response ( J:69473 )

• heavy infiltration of lymphocytes into various organs in older mice

liver inflammation ( J:69473 )

• clusters of lymphocytes in liver parenchyma

kidney inflammation ( J:69473 )

• immunoglobulin complex deposited in glomeruli

lung inflammation ( J:69473 )

• perivascular and interalveolar infiltration of mononuclear cells

growth/size/body

cachexia ( J:69473 )

• start to show signs of wasting at 15-16 months of age

enlarged spleen ( J:69473 )

• expanded numbers of T and B lymphocytes

hematopoietic system

enlarged spleen ( J:69473 )

• expanded numbers of T and B lymphocytes

abnormal lymphocyte physiology ( J:69473 )

increased B cell proliferation ( J:69473 )

• hyperresponsive to surface IgM crosslinking agents

increased T cell proliferation ( J:69473 )

• enhanced proliferative response to T cell receptor stimulation, even in younger mice

increased immunoglobulin level ( J:69473 )

• kappa and lambda light chain levels elevated

increased IgA level ( J:69473 )

• in older mice

increased IgG1 level ( J:69473 )

• elevated IgG1 levels in older mice

liver/biliary system

liver inflammation ( J:69473 )

• clusters of lymphocytes in liver parenchyma

respiratory system

lung inflammation ( J:69473 )

• perivascular and interalveolar infiltration of mononuclear cells

renal/urinary system

kidney inflammation ( J:69473 )

• immunoglobulin complex deposited in glomeruli

cellular

increased B cell proliferation ( J:69473 )

• hyperresponsive to surface IgM crosslinking agents

increased T cell proliferation ( J:69473 )

• enhanced proliferative response to T cell receptor stimulation, even in younger mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autoimmune disease		DOID:417	OMIM:109100	J:69473