Phenotypes Associated with This Genotype

Genotype
MGI:3639713

• Allelic Composition: Tg(APP695)3Dbo/0; Tg(PSEN1dE9)S9Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:87691 , J:104236 )

• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)

• 150% increase in amyloid beta peptide 42 (J:87691)

• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

homeostasis/metabolism

amyloid beta deposits ( J:87691 , J:104236 )

• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)

• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)

• 150% increase in amyloid beta peptide 42 (J:87691)

• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:123534
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:123534
Alzheimer's disease 4		DOID:0110040	OMIM:606889	J:123534