Phenotypes Associated with This Genotype

Genotype
MGI:3640329

• Allelic Composition: Gnmt^tm1Cwa/Gnmt^tm1Cwa
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:110257 )

• free methionine are increased to 700 nmol/g liver and S-adenosylmethionine levels are increased to 1334 nmol/g liver compared to 100 and 37 nmol/g liver, respectively, in wild-type mice

• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is increased about 100 fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glycine N-methyltransferase deficiency		DOID:0111037	OMIM:606664	J:110257