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Phenotypes Associated with This Genotype
Genotype
MGI:3640479
Allelic
Composition		 Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic
Background		 NOD.129S4-Tnfsf4tm1Shr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf4tm1Shr mutation (3 available); any Tnfsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:86926 )
• NOD mice homozygous for Tnfsf4tm1Shr and homozygous at the NOD alleles Idd1, Idd3, Idd5 and Idd10 are completely protected from diabetes during 30 weeks of observation while wild-type NOD controls show the expected course and penetrance of diabetes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:86926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory