Phenotypes Associated with This Genotype

Genotype
MGI:3640608

• Allelic Composition: Tg(Myh6-Pfkfb3)7Pne/0
• Genetic Background: FVB-Tg(Myh6-Pfkfb3)7Pne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac muscle glycogen level ( J:94475 )

• glycogen is increased by more than 2-fold in hearts

increased heart weight ( J:94475 )

• show a small but significant increase in heart weight of about 10%

cardiac hypertrophy ( J:94475 )

• heart weight/body weight ratio is increased, indicating mild hypertrophy

cardiac fibrosis ( J:94475 )

abnormal cardiovascular system physiology ( J:94475 )

• perfused hearts exhibit inhibited glycolysis

decreased cardiac muscle cell glucose uptake ( J:94475 )

• hearts exhibit a decrease in glucose consumption at the end of a 50-min perfusion with insulin

decreased cardiac muscle contractility ( J:94475 )

• myocytes show significantly reduced contractility as assessed by +dl/dt, -dl/dt, and % peak shortening both under normoxic and hypoxic conditions and require more time to relengthen than controls

homeostasis/metabolism

abnormal glucose homeostasis ( J:94475 )

• glucose 6-phosphate and fructose 6-phosphate levels are elevated more than 2-fold and fructose 1,6-biphospate level is decreased about 2-fold in hearts

increased cardiac muscle glycogen level ( J:94475 )

• glycogen is increased by more than 2-fold in hearts

muscle

increased cardiac muscle glycogen level ( J:94475 )

• glycogen is increased by more than 2-fold in hearts

decreased cardiac muscle cell glucose uptake ( J:94475 )

• hearts exhibit a decrease in glucose consumption at the end of a 50-min perfusion with insulin

decreased cardiac muscle contractility ( J:94475 )

• myocytes show significantly reduced contractility as assessed by +dl/dt, -dl/dt, and % peak shortening both under normoxic and hypoxic conditions and require more time to relengthen than controls

cellular

decreased cardiac muscle cell glucose uptake ( J:94475 )

• hearts exhibit a decrease in glucose consumption at the end of a 50-min perfusion with insulin

growth/size/body

increased heart weight ( J:94475 )

• show a small but significant increase in heart weight of about 10%

cardiac hypertrophy ( J:94475 )

• heart weight/body weight ratio is increased, indicating mild hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
extrinsic cardiomyopathy		DOID:3978		J:94475