Phenotypes Associated with This Genotype

Genotype
MGI:3652733

hm1

• Allelic Composition: Cd4^tm1Jrp/Cd4^tm1Jrp
• Genetic Background: either: B6.129S2-Cd4^tm1Jrp or B10.Cg-Cd4^tm1Jrp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:45168 )

• in single positive thymocytes and on splenic T cells, level of CD4 is 80% that in wild-type

decreased double-positive T cell number ( J:45168 )

• level of CD4 is 50% that in wild-type

decreased CD4-positive, alpha-beta T cell number ( J:45168 )

• reduction in CD4 compartment is 19.1%; there is a decrease in Cd4+ cells in thymus

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• there is an increase of 67.1% in CD8+ cells in thymus

hematopoietic system

abnormal T cell differentiation ( J:45168 )

• in single positive thymocytes and on splenic T cells, level of CD4 is 80% that in wild-type

decreased double-positive T cell number ( J:45168 )

• level of CD4 is 50% that in wild-type

decreased CD4-positive, alpha-beta T cell number ( J:45168 )

• reduction in CD4 compartment is 19.1%; there is a decrease in Cd4+ cells in thymus

increased CD8-positive, alpha-beta T cell number ( J:45168 )

• there is an increase of 67.1% in CD8+ cells in thymus