Phenotypes Associated with This Genotype

Genotype
MGI:3652735

cx2

• Allelic Composition: Cd4^tm1Jrp/Cd4^tm1Jrp; Tg(TcrAND)53Hed/0
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6 * SJL) or (involves: 129S2/SvPas * C57BL/6 * C57BL/10 * SJL)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates

abnormal T cell number ( J:45168 )

• mutant thymus has a 58% reduction in CD4+ thymocytes compared to littermates that only expressing the transgene

hematopoietic system

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates

abnormal T cell number ( J:45168 )

• mutant thymus has a 58% reduction in CD4+ thymocytes compared to littermates that only expressing the transgene

endocrine/exocrine glands

thymus hyperplasia ( J:45168 )

• thymi have considerably greater cellularity (33-113% more cells) than littermates