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Phenotypes Associated with This Genotype
Genotype
MGI:3653035
Allelic
Composition
Il3ram1/Il3ram1
Genetic
Background
A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il3ram1 mutation (12 available); any Il3ra mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• CFU-GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3, but normal colony growth occurs in response to GM-CSF
• Il3 alone does not support granulocyte/macrophage colony formation in bone marrow cells from A/J mice but does in bone marrow from C57BL/6 controls; costimulation with both Il3 and SCF increases the number of colonies formed compared to SCF alone

immune system
• Il3 alone does not support granulocyte/macrophage colony formation in bone marrow cells from A/J mice but does in bone marrow from C57BL/6 controls; costimulation with both Il3 and SCF increases the number of colonies formed compared to SCF alone


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory