homeostasis/metabolism
|
• levels are similar to those in Phex-deficient mice
|
|
• male mice show a ~3-fold increase in serum 1,25(OH)2D3 compared to Phex-null mice
|
skeleton
long femur
(
J:110579
)
|
• femur length is increased over Phex homozygotes
|
|
• male mice display a small but significant increase in bone mineral density compared to Phex-null mice
|
limbs/digits/tail
long femur
(
J:110579
)
|
• femur length is increased over Phex homozygotes
|
growth/size/body
|
• male mice have lower body weight than wild-type but it is increased over Phex homozygotes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
X-linked dominant hypophosphatemic rickets | DOID:0050445 |
OMIM:307800 |
J:110579 |