Phenotypes Associated with This Genotype

Genotype
MGI:3654321

• Allelic Composition: Pjvk^tm1Ugds/Pjvk^tm1Ugds
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:111260 )

N • no balance defects are seen, indicating that the vestibular system is functioning normally

abnormal auditory brainstem response waveform shape ( J:111260 )

• increased thresholds are associated with abnormal shapes and reduced amplitudes of all 4 the auditory brainstem response waves

increased or absent threshold for auditory brainstem response ( J:111260 )

• at P30 thresholds are increased at high frequencies (32-40 kHz) and this hearing loss is stable in mice up to 8 months of age (non-progressive)

• in 2 of 18 thresholds are also increased in the mid frequency range and in 2 of 18 thresholds are increased at all frequencies

• however, cochlear morphology is similar to wild-type

nervous system

nervous system phenotype ( J:111260 )

N • no brainstem morphological abnormalities are detected

behavior/neurological

behavior/neurological phenotype ( J:111260 )

N • mice behaved similar to controls in tests for motor coordination and for perception of touch and pain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive nonsyndromic deafness 59		DOID:0110511	OMIM:610220	J:111260