Phenotypes for Dmd Foxk1 MGI:3655090 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Y Foxk1^tm1Djg/Foxk1^tm1Djg
Genetic Background	involves: 129S4/SvJae * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (154 available)
Foxk1^tm1Djg mutation (0 available); any Foxk1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:62225 )

• all are dead by 3 months of age

postnatal lethality, incomplete penetrance ( J:62225 )

• die within a few weeks of birth

• few survive beyond weaning

behavior/neurological

weakness ( J:62225 )

• fragile and weak

decreased locomotor activity ( J:62225 )

muscle

skeletal muscle fibrosis ( J:62225 )

• fibrosis in muscles of the chest wall, the diaphragm and the intercostals

skeletal muscle necrosis ( J:62225 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:62225

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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