About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3655296
Allelic
Composition		 Lig4tm1Icrf/Lig4tm1Icrf
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Icrf mutation (0 available); any Lig4 mutation (46 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (239 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:111068 )
• pro-B cell lymphomas develop by 12 weeks of age
increased medulloblastoma incidence ( J:111068 )
• mice develop tumors by 12 weeks of age

nervous system
increased medulloblastoma incidence ( J:111068 )
• mice develop tumors by 12 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
 J:173443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory