Phenotypes for Foxc1 Tyr MGI:3655825 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Foxc1^tm1Blh/Foxc1⁺ Tyr^c-2J/Tyr^c-2J
Genetic Background	B6.Cg-Tyr^c-2J Foxc1^tm1Blh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^tm1Blh mutation (0 available); any Foxc1 mutation (29 available)
Tyr^c-2J mutation (26 available); any Tyr mutation (379 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal aqueous drainage system morphology ( J:82280 )

• albino mice had severe and more extensive angle developmental defects than pigmented Foxc1^tm1Blh /Foxc1⁺ mice

absent Schlemm's canal ( J:82280 )

• a small or absent Schlemm's canal

abnormal trabecular meshwork morphology ( J:82280 )

• basal lamina extending from the cornea over the trabecular meshwork

iris synechia ( J:82280 )

• broad synechiae occupies the region where the trabecular meshwork is normally located

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
buphthalmos		DOID:11211	OMIM:231300	J:82280

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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