Phenotypes Associated with This Genotype

Genotype
MGI:3655835

• Allelic Composition: Lep^ob/Lep^ob
• Genetic Background: D2.Cg-Lep^ob/Chua

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:78850 )

homeostasis/metabolism

hyperglycemia ( J:78850 )

• at 3 months of age, males are hyperglycemic with blood glucose levels of ~574 mg/dl; females have levels of ~388 mg/dl

increased circulating insulin level ( J:78850 )

• some mutant DBA/2J mice have high insulin levels compared to controls

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:78850 )

• islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium

decreased pancreatic beta cell number ( J:78850 )

• mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants

increased pancreatic beta cell number ( J:78850 )

• there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:78850