Phenotypes Associated with This Genotype

Genotype
MGI:3655854

• Allelic Composition: Krt1^Mhdadsk12/Krt1⁺
• Genetic Background: C3HeB/FeJ-Krt1^Mhdadsk12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal skin pigmentation ( J:108758 )

• increased epidermal pigment in the tips of the rete ridges and within the eccrine ducts

hyperpigmentation ( J:108758 )

• excessive pigmentation in heterozygous animals, most notably in volar pads, intervolar pad scales, and the digit tips

integument

hyperkeratosis ( J:108758 )

• observed in footpads

• thick, brown hyperkeratotic plaques are seen on the footpads of adults

acanthosis ( J:108758 )

• observed in footpads

blistering ( J:108758 )

• immediately after birth, animals develop blisters and erosions at the sites of friction

• this phenotype diminishes with the onset of hair growth

scaly skin ( J:108758 )

• by two weeks of age, blistering and erosions are replaced by scaling

abnormal skin pigmentation ( J:108758 )

• increased epidermal pigment in the tips of the rete ridges and within the eccrine ducts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epidermolytic hyperkeratosis		DOID:4603	OMIM:PS113800	J:108758