Phenotypes Associated with This Genotype

Genotype
MGI:3655962

• Allelic Composition: Tg(YACW408A5)1952Ricc/0
• Genetic Background: involves: 129/Sv * SD7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

fetal growth retardation ( J:96366 )

• at birth, mice with maternal transmission are ~18% growth-retarded compared to wild-type littermates; mice with paternal transmission are not different from wild-type mice

• two active maternal alleles of maternally expressed genes in the IC2 region results in prenatal growth retardation

cellular

abnormal imprinting ( J:96366 )

• prenatal growth retardation is observed with maternal inheritance of the transgene and resulting expression of 2 copies of maternally expressed imprinting center 2 (IC2) genes (1 endogenous, 1 trangenic)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Beckwith-Wiedemann syndrome		DOID:5572	OMIM:130650	J:96366