Phenotypes Associated with This Genotype

Genotype
MGI:3655986

cx8

• Allelic Composition: Xrcc5^tm1Dbr/Xrcc5^tm1Dbr; Lig4^tm1Fwa/Lig4^tm1Fwa
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:80467 )

N • a small number of ^tm1Fwa, Xrcc5^tm1Dbr null animals (4/131) have reached maturity and are viable; this is equivalent to observed viability of Xrcc5-null animals

prenatal lethality, incomplete penetrance ( J:80467 )

• 4/131 Lig4/Xrcc5 double null animals have been live born compared to total lethality of Lig4 single null animals

immune system

abnormal lymphocyte morphology ( J:80467 )

• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

hematopoietic system

abnormal lymphocyte morphology ( J:80467 )

• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

digestive/alimentary system

abnormal small intestine morphology ( J:80467 )

• small intestines show smaller villi relative to wild-type and Xrcc5-deficient mice

cellular

chromosome breakage ( J:80467 )

• numbers of cultured cells show similar total percentage of chromosome aberrations to Xrcc4-deficient cells (~60% vs ~10% of wild-type cells)