Phenotypes for Cdkn2a Lig4 MGI:3656001 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Lig4^tm1Fwa/Lig4^tm1Fwa
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Lig4^tm1Fwa mutation (2 available); any Lig4 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:63078 )

• no doubly-deficient offspring are observed (0/170)

• numbers of double heterozygotes observed are similar to expected numbers

cellular

decreased cell proliferation ( J:63078 )

• MEFs show premature growth arrest compared to wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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