Phenotypes Associated with This Genotype

Genotype
MGI:3656002

cx32

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺; Lig4^tm1Fwa/Lig4^tm1Fwa
• Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:63078 )

• no doubly-deficient offspring are observed (0/170)

• numbers of double heterozygotes observed are similar to expected numbers

cellular

increased cellular sensitivity to ionizing radiation ( J:63078 )

• cells are highly sensitive to ionizing radiation compared to wild-type or Cdkn2a-deficient MEFs

increased neuron apoptosis ( J:63078 )

• high levels of pyknotic cells are observed in doubly-deficient embryos

decreased cell proliferation ( J:63078 )

• MEFs show premature growth arrest compared to wild-type MEFs

nervous system

increased neuron apoptosis ( J:63078 )

• high levels of pyknotic cells are observed in doubly-deficient embryos