Phenotypes Associated with This Genotype

Genotype
MGI:3656004

cx6

• Allelic Composition: Lig4^tm1Fwa/Lig4^tm1Fwa; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:63078 )

• majority of mice die at less than 8 weeks of age, with a significant drop in survival at ~3 weeks of age

prenatal lethality, incomplete penetrance ( J:63078 )

• embryonic lethality is dramatically abrogated in double mutants (20/369 double null offspring) compared to nearly total lethality with Lig4-deficiency alone (8/369 observed)

• numbers of double heterozygotes observed are similar to expected numbers

growth/size/body

decreased body weight ( J:63078 )

• postnatally, mice are much smaller (only 25% of control littermate weight) than wild-type or doubly-heterozygous littermates

nervous system

decreased neuron apoptosis ( J:63078 )

• neuronal apoptosis is significantly rescued with Trp53 haploinsufficiency

cellular

decreased neuron apoptosis ( J:63078 )

• neuronal apoptosis is significantly rescued with Trp53 haploinsufficiency