Phenotypes Associated with This Genotype

Genotype
MGI:3656138

hm1

• Allelic Composition: Ahr^tm1Gonz/Ahr^tm1Gonz
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:36360 )

• interperitoneal injection of 2000 ug/kg TCDD fails to induce thymic cortical atrophy, changes in thymic lymphocyte numbers, increased hepatic lipid accumulation, or increases in liver weight all of which are seen in wild-type and heterozygous mice injected with 200 ug/kg TCDD

• interperitoneal injection of 2000 ug/kg TCDD but not 200 ug/kg does induce a significant increase in lymphocyte and marcophage infiltrates and perivascular cuffs in the lung which are seen in wild-type and heterozygous mice exposed to200 ug/kg TCDD

reproductive system

reproductive system phenotype ( J:76280 )

N • mammary gland development is normal