mortality/aging
|
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates
|
homeostasis/metabolism
|
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized
• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed
|
cardiovascular system
|
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition
|
hemorrhage
(
J:44497
)
|
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed
|
|
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates
|
hematopoietic system
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
|
immune system
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
|
growth/size/body
|
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hemophilia B | DOID:12259 |
OMIM:306900 |
J:44497 |