Phenotypes Associated with This Genotype

Genotype
MGI:3662854

• Allelic Composition: Fgg^tm1Fjc/Fgg^tm1Fjc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:64396 )

• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages, although hemorrhages around the cranial, neck, and nasal areas are also observed

• however, many homozygotes are able to resolve the bleeding and recover

internal hemorrhage ( J:64396 )

• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages

uterine hemorrhage ( J:75302 )

♀ • excessive maternal bleeding is detected at the implantation site in the uterus as early as E6

vaginal hemorrhage ( J:75302 )

• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7

homeostasis/metabolism

abnormal blood coagulation ( J:64396 )

• homozygotes exhibit significantly delayed thrombin-induced plasma clot times (>17 min) relative to wild-type mice (35.5 3.5 sec)

reproductive system

uterine hemorrhage ( J:75302 )

♀ • excessive maternal bleeding is detected at the implantation site in the uterus as early as E6

vaginal hemorrhage ( J:75302 )

• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7

increased miscarriage rate ( J:75302 )

♀ • at E6, embryos in the uteri of pregnant female homozygotes show severe bleeding in regions around the ectoplacental cone, resulting in blood-filled lacunae at E8 to E9

♀ • by E9 large areas of bleeding initiate the disruption of the placenta and yolk sac from the endometrium

♀ • pregnant female homozygotes undergo spontaneous abortion, with resulting maternal death at E9.75 through excessive bleeding

♀ • a minimal dosage schedule of 10 mg of fibrinogen at E8.5 and E17.5 rescues pregnancy and results in successful vaginal deliveries

embryo

decreased embryo size ( J:75302 )

• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity

abnormal placenta morphology ( J:75302 )

• at E9.75, placental detachment occurs from the implantation site

abnormal placenta labyrinth morphology ( J:75302 )

• afibrinogenemic pregnant females show detachment of the fibrinoid layer from the decidua and disruption of sinusoids of the labyrinths with severe hemorrhage along the planes of placental-decidual attachment

small placenta ( J:75302 )

• at E9, embryos obtained from pregnant female homozygotes display a smaller placenta

abnormal visceral yolk sac morphology ( J:75302 )

• at E9.75, embryos obtained from female pregnant homozygotes display a significantly smaller yolk sac

abnormal placenta development ( J:75302 )

• female homozygotes exhibit abnormal development of fetal-maternal vascular communication and stabilization of embryo implantation

growth/size/body

decreased embryo size ( J:75302 )

• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity

respiratory system

respiratory system phenotype ( J:64396 )

N • in response to bleomycin-induced acute lung injury, homozygotes show no significant differences in the deposition of interstitial collagen and pulmonary fibrotic lesions at 7 and 14 days after intratracheal administration of bleomycin relative to wild type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital afibrinogenemia		DOID:2236	OMIM:202400	J:75302